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Download PDF by S. O. Warnaar (auth.), Dirk J. Ruiter, Gert Jan Fleuren,: Application of Monoclonal Antibodies in Tumor Pathology

By S. O. Warnaar (auth.), Dirk J. Ruiter, Gert Jan Fleuren, Sven O. Warnaar (eds.)

ISBN-10: 9400932995

ISBN-13: 9789400932999

ISBN-10: 9401079811

ISBN-13: 9789401079815

The improvement of monoclonal antibodies to human tumor linked antigens has vastly facilitated the applying of immunohistochemical suggestions to investigate surgically got rid of tissues. over the last few years this process has been used by a gradually expanding variety of investigators to research malignant cells. even if monoclonal antibodies to tumor linked antigens haven't develop into but regimen reagents in immunopathology, they've got supplied new info which may no longer be bought with traditional antisera or histochemical approaches. the subsequent are consultant examples. TUmor linked antigens were pointed out which demonstrate a constrained distribution in common tissues and accordingly may possibly symbolize valuable markers for radio­ imaging and acceptable goals for immunotherapy. even with undetec­ desk adjustments with traditional histopathological ways hetero­ geneity has been present in the antigenic profile of tumor cells inside of a lesion, in autologous lesions faraway from diversified anatomic websites from a given sufferer and in lesions faraway from diverse sufferers. Phenotypes of tumor cells were pointed out which correlate with the biology of tumor cells and with the medical process the affliction. From a realistic view aspect using monoclonal antibodies in immunopathology has greater interactions among pathologists and immunologists, as exemplified by way of the current booklet. Such interactions have contributed to the appliance of uncomplicated learn to scientific difficulties. The bankruptcy of this booklet speak about investigations played with monoclonal antibodies to antigens expressed through numerous forms of general and malignant human cells.

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Additional resources for Application of Monoclonal Antibodies in Tumor Pathology

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Blood 1985, 65, 764-768. 33. Herbrink P, van Bussel F, Warnaar so. The antigen spot test (AST): a highly sensitive assay for the detection of antibodies. J. Immunol. Meth. 1982, 48, 293-298. 36 34. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels into nitrocellulose sheets: procedure and some applications. Sci. USA 1979, 76, 4350-4354. Rosenthal 35. Thornthwaite JT, Seckinger D, Sugarbaker EV, PK, Vazquez DA. Dual immunofluorescent analysis of human peripheral blood lymphocytes.

25. Bondi A, Chieregatti G, Eusebi V, Fulcheri E, Bussolatti G. The use of beta-galactosidase as a tracer in immunocytochemistry. Histochemistry 1982, 76, 153-158. 26. Faulk WP, Taylor GM. An electron microscope. 1081-1083. 27. De Mey J. Colloidal gold probes in immunocytochemistry. ). Wright, Bristol. 1983, pp. 82-112. immunocolloid method for Immunochemistry 1971, the 8, 28. Geuze H, Slot J, van der Ley P, Schutter R, Griffith J. Use of colloidal gold particles in double labeling immuno-electron microscopy of ultrathin frozen tissue sections.

Secondly immunofluorescence preparations cannot be dehydrated and permanently mounted and are therefore difficult to store for prolonged periods of time. The introduction of the horseradish peroxidase labeled antibody method by Nakane and Pierce in 1966 (2) was a major breakthrough. Enzyme labels result in coloured end-products which can be examined by regular transmission light microscopy and counterstaining of the preparation allows the recognition of morphological features as in ordinary light microscopy.

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Application of Monoclonal Antibodies in Tumor Pathology by S. O. Warnaar (auth.), Dirk J. Ruiter, Gert Jan Fleuren, Sven O. Warnaar (eds.)


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