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Download e-book for iPad: Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

ISBN-10: 9048158818

ISBN-13: 9789048158812

ISBN-10: 9401597219

ISBN-13: 9789401597210

This quantity is the complaints of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene learn: easy technological know-how and New medical functions, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of protecting either uncomplicated and scientific facets of prostaglandin and leukotriene study.

At this assembly specific emphasis used to be given to the capability software of the unconventional COX-2 inhibitors, the genetics of bronchial asthma on the subject of the creation of leukotrienes, and novel mobile networks for the construction of leukotrienes and lipoxins.

Traditionally, as has been performed in earlier conferences of this sequence, a large amount of new fabric was once awarded and mentioned this 12 months, with specific awareness given to the latest medical data.

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Extra info for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

Sample text

A similar pattern ofboth 12-LOX metabolites was also observed when 12-HPETE was added exogenously (data not shown). Since PHGPx and GPx-1 lower the hydroperoxide tone in the cells, there occurs inevitably a modulation ofthe AA metabolism. 1 nmol without iodoacetate), whereas almost no hepoxilin was detected in platelets in the absence of iodoacetate. To our knowledge this role of PHGPx has not been reported so far. Considering that hepoxilins are involved in a number of biological effects in mammalian cells [2,11,12], it is reasonable to assume that the shift of the reduction route of 12-LOX pathway to the isomerization route occurs inevitably under oxidative stress situation in order to keep the functional integrity of the platelets.

Another general means by which 5-LO localization may influence metabolie function of the enzyme involves its eapacity to interaet with downstream enzymes. The major 5-LO product of alveolar macrophages is L TB 4 • Synthesis ofthis moleeule requires the hydrolysis of 5-LO-derived LTA4 by the enzyme LTA4 hydrolase. Preliminary data derived from both in situ (immunohistochemical staining of lung tissue) and ex vivo (immunofluoreseence microscopy and subcellular fractionation of isolated cells) studies indicate that in alveolar macrophages, LT~ hydrolase is found in both cytosolic and intranuclear compartments.

Riddick CA, Serio KJ, Hodulik CR, Ring WL, Regan MS, Bigby TD. TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cellline, THP-1. J Immunol 1999; 162:1101-7. , Petersen J, Austen KF. Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP. J Clin Invest 1991;87:1958-63. Cowburn AS, Sladek K, Soja J, et al. Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

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Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)


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